Andre Goy, MD
Exciting developments in the treatment of patients with lymphoma were highlighted at the 2018 ASCO Annual Meeting, said Andre Goy, MD, holding out the possibility of treating patients without chemotherapy and even treatment-free remission.
, Goy, chairman and director, chief of Lymphoma, and director of Clinical and Translational Cancer Research at John Theurer Cancer Center, discussed some of the most important lymphoma data presented at the 2018 ASCO Annual Meeting and potential future directions for treatment.
OncLive: What were some of the highlights of this year’s ASCO Annual Meeting?
Five years ago, we did not think that immunotherapy would be where it is now. This was one of the first topics that is all over ASCO and is changing the field.
There were also data presented from the TRANSCEND trial on JCAR017, and it was really interesting that it did as well as it did because there seems to be a little bit less CRS and it seems to be more durable and effective as an outpatient [treatment]. In a higher-dose cohort, their CR is in a high of 40% and a response rate around 80%. And that is, again, regardless of prior therapy.
What other research in lymphoma are you excited about?
There are ongoing studies; there are actually more than 300 studies in the United Studies and 300 in China and Europe in CAR T-cell therapies and combinations with checkpoint inhibitors, to see how we can build up these combinations. It is very exciting.
In terms of immunotherapy, there was also the first presentation of an anti-CD47, which is a macrophage checkpoint inhibitor. That was done in combination with rituximab (Rituxan). It's early, a small study, but a proof-of-concept trial that some macrophages are very important and that's another area that will be very promising in the future.
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