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HCC Armamentarium Expands, With Promising Agents on the Horizon

Brandon Scalea
Published: Tuesday, Mar 05, 2019

Aiwu Ruth He, MD, PhD

Aiwu Ruth He, MD, PhD

Several positive trials in advanced hepatocellular carcinoma (HCC) have led to an influx of available treatment options in a field that had become relatively stagnant, said Aiwu Ruth He, MD, PhD, and more promising agents are coming down the pike.

State of the Science Summit™ on Gastrointestinal Cancers, He, an associate professor of medicine at Georgetown-Lombardi Comprehensive Cancer Center, discussed the newly crowded treatment landscape of HCC and highlighted next steps for research.

OncLive: What agents have entered the HCC treatment paradigm in recent years?

He: In the frontline setting, we have 2 TKIs: sorafenib and lenvatinib. Sorafenib was FDA approved in 2007. Lenvatinib was just approved last year, supported by data from the pivotal REFLECT trial. In the second-line setting, we now have 2 TKIs and 2 immune checkpoint inhibitors available. Regorafenib, a TKI, was approved by the FDA in 2017 for use in patients who have tolerated sorafenib and progressed on the drug. This [regulatory decision] was supported by positive data from the RESORCE trial. Cabozantinib was FDA approved in January 2019, based on results from the CELESTIAL trial.
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