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High Rates of Symptoms, Impairment, With Myeloproliferative Neoplasms

Published: Tuesday, Dec 20, 2016

Claire N. Harrison, DM

Claire N. Harrison, MD

Patients with myeloproliferative disorders have a high symptom burden that significantly affects emotional status, quality of life, and functional ability, an international patient survey showed.

Fatigue or tiredness was the single most common symptom, reported by 64%, 54%, and 45% of patients with ET, MF, and PV, respectively. The types of symptoms and symptom burden varied by MPN type:
  • MF—Abdominal discomfort (30%), shortness of breath (29%), night sweats (29%), and difficulty sleeping (27%)
  • PV—Pruritus (28%), loss of concentration (27%), night sweats (25%), and dizziness (25%)
  • ET—Dizziness (33%), night sweats (31%), bruising (30%), and difficulty sleeping (28%)
Similarly, fatigue ranked at the top of the list of “most severe symptoms” for patients with all 3 types of MPNs. The mean severity scores for fatigue (scale of 0-10) were 6.68 for MF, 6.53 for PV, and 6.44 for ET. “Inactivity” followed, with mean scores of 6.7 for MF, 5.97 for ET, and 5.54 for PV. Patients with ET had a mean severity score of 7.89 for “other symptoms not listed” and 6.92 for blood clots.
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