Persistent HPV 16/18 infection correlated with higher locoregional relapse, overall relapse, and was also associated with early relapses in women with locally advanced cervical cancers treated with radical radiochemotherapy.
On univariate analyses, FIGO stage, nodal status, pretreatment hemoglobin level, radiation dose, clinical response, and HPV infection status at 9 months and 24 months’ posttreatment had a significant impact on relapse-free survival (RFS), locoregional control (LRC), and overall survival (OS). However multivariate analysis showed that only nodal status and pretreatment hemoglobin had a significant impact on RFS and OS, while persistent HPV infection by 24 months affected LRC and RFS.
Mahantshetty U, Tanuja T, Pushpa N, et al. Impact of HPV 16/18 infection on clinical outcomes in locally advanced cervical cancers treated with radical radio (chemo) therapy - A prospective observational study [published online December 1, 2017]. Gynecol Oncol doi: 10.1016/j.ygyno.2017.11.034.
... to read the full story