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HPV Subtypes Linked to Development of High-Grade Cervical Cancer

Caroline Seymour
Published: Thursday, Jan 03, 2019

Sonia Andersson, MD, PhD

Sonia Andersson, MD, PhD

The presence of specific subtypes of HPV, namely HPV-16 and -18, were found to be associated with a higher risk of developing high-grade cervical intraepithelial neoplasia (CIN) in women under the age of 30, according to results of a nested case-control Swedish study published in Cancer.

“Women younger than 30 with a positive HPV-16 or HPV-18 finding need to be closely followed, whereas other HPV types are much less likely to be associated with increased risk in these younger women,” concluded Andersson. “Among women above age 30, any HPV-positive finding should be closely followed.”
Fröberg M, Östensson E, Belkić K, et al. The impact of HPV status on development of high-grade cervical intraepithelial neoplasia in women negative for intraepithelial lesions or malignancy at baseline: 9-year Swedish nested case-control follow-up study [published online December 10, 2018]. Cancer. doi: 10.1002/cncr.31788.

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