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Ibrutinib/Rituximab Emerges as New Standard in Waldenstrom Macroglobulinemia

Jason Harris
Published: Monday, Jul 23, 2018

 Meletios A. Dimopoulos, MD

Meletios A. Dimopoulos, MD
Results from the phase III iNNOVATE (PCYC-1127) trial established the combination of ibrutinib (Imbruvica) plus rituximab (Rituxan) as the new standard of care in Waldenström macroglobulinemia, said Meletios A. Dimopoulos, MD.

, Dimopoulos discussed what he hopes to see in the final analysis of iNNOVATE and the development of future treatments for Waldenström macroglobulinemia.

OncLive: What was the rationale for this trial?

Dimopoulos: Waldenström macroglobulinemia is an unusual, low-grade lymphoplasmacytic lymphoma. Among active treatments for this disease, we have the anti-CD20 monoclonal antibody rituximab, which has been around for 25 years. It is one of the most frequent therapies given as a single agent. Among other agents, we have nucleoside analogues, we have proteasome inhibitors, and in the past few years, there has been a significant interest for treating this disease with BTK inhibitors. The first one was ibrutinib.
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