IKZF1 deletions that co-occurred with deletions in CDKN2A, CDKN2B, PAX5,
in the absence of ERG deletion (IKZF1plus
) were associated with a dramatically reduced prognosis in pediatric patients with B-cell precursor (BCP) acute lymphoblastic leukemia (ALL).
,” wrote Stanulla et al.
Stanulla M, Dagdan E. Zaliova M, et al. IKZF1plus defines a new minimal residual disease–dependent very-poor prognostic profile in pediatric b-cell precursor acute lymphoblastic leukemia [published online March 2, 2018]. J Clin Oncol. doi: 10.1200/JCO.2017.74.3617.
... to read the full story