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IKZF1 Deletions Predict Poor Prognosis in Pediatric ALL

Jason Harris
Published: Tuesday, Mar 06, 2018

IKZF1 deletions that co-occurred with deletions in CDKN2A, CDKN2B, PAX5, or PAR1 in the absence of ERG deletion (IKZF1plus) were associated with a dramatically reduced prognosis in pediatric patients with B-cell precursor (BCP) acute lymphoblastic leukemia (ALL).

,” wrote Stanulla et al.
Stanulla M, Dagdan E. Zaliova M, et al. IKZF1plus defines a new minimal residual disease–dependent very-poor prognostic profile in pediatric b-cell precursor acute lymphoblastic leukemia [published online March 2, 2018]. J Clin Oncol. doi: 10.1200/JCO.2017.74.3617.

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