Ipilimumab (Yervoy) was associated with a 1-year overall survival (OS) rate of 75% in adolescent patients with stage III/IV unresectable malignant melanoma.
One patient in the 3 mg/kg cohort and 5 in the 10 mg/kg grout reported experiencing grade 3/4 immune-mediated adverse reactions. There were no treatment-related deaths recorded. However, half of the patients in the 3 mg/kg cohort and 3 (38%) in the 10 mg/kg cohort died from disease progression at the time of study closure.
Geoerger B, Bergeron C, Gore L, et al. Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma. Eur J Cancer. 2017;86:358-363. doi:10.1016/j.ejca.2017.09.032.
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