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Lead Researcher Highlights Tisagenlecleucel Benefit in Younger Leukemia Patients

Caroline Seymour
Published: Wednesday, Jan 02, 2019

Dr. Stephan Grupp

Stephan Grupp, MD, PhD

The CD19-targeted CAR T-cell therapy, tisagenlecleucel (Kymriah) demonstrated durable remissions in pediatric and young adult patients with relapsed/refractory acute lymphoblastic leukemia (ALL), according to an updated analysis of the phase II ELIANA trial presented by Stephen Grupp, MD, PhD, at the 2018 ASH Annual Meeting.

during the 2018 ASH Annual Meeting, Grupp, the director of translational research for the Center for Childhood Cancer Research at the Children's Hospital of Philadelphia (CHOP) and medical director of the Stem Cell Laboratory at CHOP, discussed the updated analysis of the ELIANA trial and its implications for pediatric and young adult patients with relapsed/refractory ALL.

OncLive: Please provide some background on the ELIANA trial.

Grupp: At the 2018 ASH Annual Meeting, we reported updated data from the ELIANA trial. ELIANA was the first registration trial with regard to CAR T-cell therapy. [The therapy] was tested in children and young adults with relapsed/refractory ALL. It’s exciting that we were able to do this in kids first. It was the first international study with the global supply chain. There were a lot of firsts in terms of understanding how the therapy works [in this population].

How was the study designed and what were the initial results?

The study was intended to evaluate how tisagenlecleucel performed in kids and young adults with relapsed/refractory ALL. Patients had to have a high disease burden. On average, they had about a 75% blast in their bone marrow when they were enrolled on the trial. The first goal [of the trial] was to see how many patients would go into remission—that was the primary endpoint—and about 82% of patients [were able to do that]. Those data have been consistent throughout the study.

Now that we have an update, we're able to say how the therapy performs long-term. We're seeing that in the 82% of patients in remission, approximately 66% are in remission at 12 and 18 months, while 62% [are in remission] at 24 months. Our median follow-up now is 24 months. That's starting to be a significant amount of time. It’s important to see that these patients are remaining in remission without needing bone marrow transplants. Only a small number of patients went to transplant.

Are there plans to bring the therapy into earlier lines of treatment?

One of the more interesting questions is when the appropriate time to deploy this therapy is. In the 5 or 6 years that we've been doing this, we see that referring doctors are calling us earlier and not waiting as long [to reach out]. These patients have lower disease burden. It's much safer to do the therapy when you have less leukemia, although we can still administer the therapy safely [in patients with] very high amounts of leukemia as well.
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