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Marshall Recaps Milestones in CRC Paradigm

Angelica Welch
Published: Wednesday, Jan 10, 2018

John L. Marshall, MD

John L. Marshall, MD
Advancements in next-generation sequencing have opened the door for therapeutic options for patients with gastrointestinal (GI) cancers. Specifically, microsatellite instability (MSI) and PD-L1 testing has allowed for patients with GI cancers to benefit from immunotherapies previously thought to have little effect in these types of tumors.

, Marshall, chief, Division of Hematology/Oncology, MedStar Georgetown University Hospital, professor of medicine and oncology, Lombardi Comprehensive Cancer Center, Georgetown University Director, Otto J. Ruesch Center for the Cure of Gastrointestinal Cancer, recapped some of the biggest CRC advancements of 2017, and explained what those successes mean for the treatment paradigm moving forward.

OncLive: Can you discuss the recent progress made in GI cancers, specifically in CRC?

Marshall: Starting at the top and working down, the new standard of care in gastroesophageal junction cancers, and in gastric cancers with the FLOT [fluorouracil, leucovorin, oxaliplatin, and docetaxel] regimen. There have been new approvals with immunotherapy in the space of gastric cancer, upper GI cancers in general, liver cancer, and CRC.
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