Michael Wang, MD,
In the ongoing phase II ZUMA-2 trial, investigators hope that the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy axicabtagene ciloleucel (axi-cel; Yescarta) can lead to a breakthrough in patients with mantle cell lymphoma (MCL) who no longer respond to treatment (NCT02601313).
“In ZUMA-2, we are aiming to overcome resistance cost in mantle cell lymphoma,” said lead author Michael Wang, MD. “[To overcome] cost by targeted therapies and immunotherapies and to overcome resistance with cell therapies.”
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