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Navitoclax Activity Confirmed in Ruxolitinib-Resistant Myelofibrosis

Caroline Seymour
Published: Thursday, Jan 30, 2020

Jacqueline S. Garcia, MD

Jacqueline S. Garcia, MD

The addition of the BCL-2/BCL-XL inhibitor navitoclax to ruxolitinib (Jakafi) led to a clinically meaningful reduction in spleen volume and improvement in symptoms in patients with primary or secondary myelofibrosis with acquired resistance to ruxolitinib, according to results of a phase II study presented at the 2019 ASH Annual Meeting.
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