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NCCN Recommends Regorafenib Dose Escalation in Metastatic CRC

Jason Harris
Published: Friday, Mar 16, 2018

Tanios Bekaii-Saab, MD

Tanios Bekaii-Saab, MD
The NCCN has updated its colorectal cancer (CRC) guidelines, recommending a weekly regorafenib (Stivarga) dose-escalation strategy beginning at 80 mg and ending at 160 mg for previously treated patients with metastatic CRC (mCRC).

“Another finding that was very intriguing was the quality of life. The quality of life of patients, when you use the dose-escalating strategy from 80 mg to 120 mg to 160 mg was not compromised…it was a straight line,” Bekaii-Saab said. “Whereby, with the higher standard dose of 160 mg, we see a drop in the quality of life that readjusts as you readjust the dose of the medication. That difference was consistent across every parameter that was included in the quality of life.”
Bekaii-Saab TS, Ou FS, Anderson DM, et al. Regorafenib dose optimization study (ReDOS): Randomized phase II trial to evaluate dosing strategies for regorafenib in refractory metastatic colorectal cancer (mCRC)—an ACCRU Network study. J Clin Oncol. 2018;36(suppl 4S; abstr 611).

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