A review of patients with locally advanced bulky squamous cell carcinoma (SCC) of the uterine cervix who underwent chemoradiation followed by surgery with pelvic lymphadenectomy showed that the technique was associated with a 5-year overall survival (OS) of 95.7%.
There were no treatment-related deaths in the study, though 1 patient died of recurrence and 2 died of unknown reasons after more than 100 months. Seven events in 4 patients led to the development of postoperative fistula formation requiring a rescue surgery. Three patients (13.0%) developed distant metastases, 1 of whom showed local recurrence later.
Nakao Y, Hashiguchi M, Nishiyama S, et al. Preoperative chemoradiotherapy in locally advanced bulky squamous cell carcinoma of the uterine cervix [published online August 3, 2017]. Int J Gynecol Cancer. doi: 10.1097/IGC.0000000000001094.
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