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Nivolumab Active in Advanced Gynecologic Cancers

Jason Harris
Published: Wednesday, Jul 19, 2017

Antoine Hollebecque, MD
Antoine Hollebecque, MD
In phase I/II results from CheckMate-358, nivolumab (Opdivo) demonstrated clinical activity in women with recurrent/metastatic cervical cancer, and was active to a lesser extent in vaginal and vulvar cancers.

“The observed safety profile was manageable and consistent with previous results seen with nivolumab monotherapy,” Hollegecque said.
Hollegecque A, Meyer T, Moore KN, et al. An open-label, multicohort, phase I/II study of nivolumab in patients with virus-associated tumors (CheckMate 358): Efficacy and safety in recurrent or metastatic (R/M) cervical, vaginal, and vulvar cancers. J Clin Oncol 35, 2017 (suppl; abstr 5504).

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