News >

Nivolumab Improves OS in Advanced or Recurrent Esophageal Cancer

Gina Columbus @ginacolumbusonc
Published: Thursday, Jan 10, 2019

Nivolumab (Opdivo) demonstrated a significant extension in overall survival (OS) versus chemotherapy in patients with unresectable advanced or recurrent esophageal cancer that is refractory to or intolerant of fluoropyrimidine plus platinum-based therapy, according to topline findings of the phase III ATTRACTION-3 study (ONO-4538-24/CA209-473).1

A collaboration agreement began in 2011 when Ono Pharmaceutical granted BMS territorial rights to develop and commercialize nivolumab worldwide except in Japan, South Korea and Taiwan, which is where ONO retained all rights to nivolumab except the United States at the time. In July 2014, Ono and BMS expanded the collaboration agreement to jointly develop and commercialize multiple immunotherapies alone and in combination for patients with cancer in Japan, South Korea and Taiwan.


  1. Opdivo® (Nivolumab) Demonstrates a Significant Extension in Overall Survival Versus Chemotherapy in Patients with Unresectable Advanced or Recurrent Esophageal Cancer in Phase III Clinical Study. ONO Pharmaceutical Co., LTD. Published January 10, 2019." . Accessed January 10, 2019.
  2. Kitagawa Y, Doki Y, Kato K, et al. Two year survival and safety update for esophageal squamous cell carcinoma treated with nivolumab (ATTRACTION-01/ONO-4538-07). Ann Oncol. 2017;28(5):mdx369.022. doi: 10.1093/annonc/mdx369.022.

... to read the full story
To Read the Full Story

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Publication Bottom Border
Border Publication