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Nivolumab/Ipilimumab Combo Misses Primary Endpoint in Phase III SCLC Trial

Gina Columbus @ginacolumbusonc
Published: Monday, Nov 26, 2018

lung cancer
The combination of nivolumab (Opdivo) and ipilimumab (Yervoy) did not improve overall survival (OS) versus placebo as a maintenance therapy for patients with extensive-stage small cell lung cancer (SCLC) without disease progression following frontline platinum-based chemotherapy, missing the primary endpoint of the phase III CheckMate-451 trial.

The median DOR was not yet reached with single-agent nivolumab. In the N3/I1 arm, the median DOR was 4.4 months (95% CI, 3.7-not reached), and was 7.7 months (95% CI, 4.0-not reached) in the N1/I3 group.


  1. Antonia SJ, Lopez-Martin JA, Bendell JC, et al. Checkmate 032: Nivolumab (N) alone or in combination with ipilimumab (I) for the treatment of recurrent small cell lung cancer (SCLC). J Clin Oncol. 2016;34 (suppl; abstr 100).
  2. Antonia SJ, Lopez-Martin JA, Bendell JC, et al. Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial. Lancet Oncol. 2016:17(7):883-895. doi: 10.1016/S1470-2045(16)30098-5.

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