The addition of weekly carboplatin following surgery and radiation therapy did not improve freedom from locoregional relapse (FFLRR) in patients with high-risk cutaneous head and neck squamous cell carcinoma (HNSCC).
The most common any-grade chemotherapy-related AE was grade 1/2 nausea, observed in 55% of CRT patients.
Porceddu SV, Bresel M, Poulsen MG, et al. Postoperative concurrent chemoradiotherapy versus postoperative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck: the randomized phase III TROG 05.01 trial [published online March 14, 2018]. J Clin Oncol. doi: 10.1200/JCO.2017.77.0941.
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