Adjuvant chemotherapy given during and after radiotherapy did not improve 5-year overall survival (OS) for patients with high-risk endometrial cancer in the phase III PORTEC-3 trial, although the treatment increased failure-free survival (FFS).1
At a median follow-up of 60.2 months (IQR, 48.1-73.1), the 5-year OS was 81.8% (95% CI, 77.5-86.2) with chemoradiotherapy versus 76.7% (95% CI, 72.1-81.6) with radiotherapy (adjusted HR, 0.76, 95% CI, 0.54-1.06; P
= .11). Five-year FFS was 75.5% (95% CI, 70.3-79.9) with chemoradiotherapy versus 68.6% (95% CI, 63.1-73.4) with radiotherapy (HR, 0.71, 95% CI, 0.53-0.95; P
“For each patient [with high-risk endometrial cancer], the cost in terms of increased toxicity and longer treatment duration should be weighed against the benefit in terms of improvement in failure-free survival,” first study author Stephanie M de Boer, MD, department of Radiation Oncology, Leiden University Medical Center, the Netherlands, and coinvestigators wrote.
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