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Novel Approaches Emerge in AL Amyloidosis

Angelica Welch
Published: Friday, Apr 27, 2018

Michael Rosenzweig, MD

Michael Rosenzweig, MD
Much like multiple myeloma, the treatment landscape of immunoglobulin light chain (AL) amyloidosis is rapidly expanding with novel systemic therapies, says Michael Rosenzweig, MD.

State of the Science Summit™ on Multiple Myeloma and Myeloproliferative Neoplasms, Rosenzweig, assistant professor in the Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, discussed these emerging treatment options for patients with AL amyloidosis.

OncLive: Can you provide an overview of your lecture on new agents in AL amyloidosis?

Rosenzweig: The standard approach to treatment today targets the underlying small plasma cell clone that is responsible for the light chains that are producing amyloid and then depositing it in organs and tissues. The goal of treatment is to attack that plasma cell clone and eliminate it. New drugs and exciting developments that have happened recently go hand in hand with the progress that has been made for multiple myeloma. Daratumumab is an exciting new drug for relapsed myeloma moving up to the frontline setting. Likewise, for AL amyloidosis, it has been studied and found to be very effective.

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Online CME Activities
TitleExpiration DateCME Credits
Advances in™ Multiple Myeloma: Changing Treatment Paradigms and the Emerging Potential of CAR T-Cell TherapyAug 30, 20191.5
2nd Annual Live Medical Crossfire®: Hematologic Malignancies OnlineSep 28, 20198.0
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