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Novel Radionuclide Treatment Shows Promise in mCRPC

Jason Harris
Published: Friday, May 11, 2018

Michael S. Hofman, MBBS

Michael S. Hofman, MBBS
Radionuclide treatment with Lutetium-177 [177Lu]-PSMA-617 nearly doubled median PSA progression-free survival (PFS) in men with progressive metastatic castrate-resistant prostate cancer (mCRPC) compared with previous results with another radiopharmaceutical, radium-223 (Ra-223; Xofigo), according to updated results from the phase II LuPSMA study published in The Lancet Oncology.

In LuPSMA, the median PSA PFS was 7.6 months (95% CI, 6.3-9.0) and 27 (90%) of 30 men experienced PSA progression. The median overall survival (OS) was 13.5 months (95% CI, 10.4-22.7) and 22 (73%) men had died by the November 2017 data cutoff.

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