Matthew S. Davids, MD, MMSc
With the introduction of novel therapies in newly diagnosed chronic lymphocytic leukemia (CLL), physicians may be moving away from historically predominant chemoimmunotherapy-based treatment approaches towards novel, fixed-duration strategies, explained Matthew S. Davids, MD, MMSc.
One such strategy is exploring the combination of venetoclax (Venclexta) and obinutuzumab (Gazyva) in patients with treatment-naïve CLL who have coexisting medical conditions. In the phase III CLL14 trial, patients were randomized to receive either 12 months of venetoclax and 6 months of obinutuzumab or 6 months of obinutuzumab followed by 6 months of chlorambucil.
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