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O'Regan Covers Scope of ER+ and HER2+ Breast Cancer Advancements

Gina Columbus @ginacolumbusonc
Published: Monday, May 22, 2017

Ruth O’Regan, MD

Ruth O’Regan, MD

Researchers are merely cracking the surface of therapeutic regimens fit for patients with estrogen receptor (ER)-positive or HER2-positive breast cancers, as great work lies ahead in immunotherapy, biomarker identification, and the optimal use of CDK 4/6 inhibition.

State of the Science Summit on Metastatic Breast Cancer, O’Regan, who also chaired the event, provided insight on the evolving landscapes of ER-positive and HER2-positive breast cancers, and what regimens remain solid approaches for effective patient outcomes.

OncLive: You had a couple of lectures at tonight’s meeting. What did you highlight in the discussion on ER-positive breast cancer?

O'Regan: Regarding endocrine therapy, 1 of the things that has come out in the last year or so is the data with fulvestrant versus anastrozole in the first-line setting. The data from the phase III randomized FALCON trial did show an improved outcome for patients who got fulvestrant at the 500-mg dosing schedule compared with anastrozole. However, the data results were not as profound as seen in the first randomized phase II study, so we will wait for more data from that study. There were data basically showing that, in patients who did not have visceral metastases, they did have quite a considerable improved outcome [with fulvestrant] versus anastrozole. I am not sure that every patient needs this in the first-line setting but, in the absence of a biomarker telling us whether a patient needs 1 or not, most of us lean toward giving those drugs to patients. 
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