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PD-1 Inhibitor Active in Advanced Liver Cancer

Published: Wednesday, Feb 01, 2017

Ignacio Melero, MD, PhD

Ignacio Melero, MD, PhD

Patients with advanced hepatocellular carcinoma (HCC) had objective responses (OR) and prolonged survival when treated with single-agent nivolumab, data from a dose escalation/expansion trial showed.

In the dose-expansion phase, a subgroup of 69 patients without exposure to sorafenib had an objective response rate of 21.7% (all partial response). An additional 43.5% of patients had stable disease. Survival at 6 and 9 months were 87% and 77%, respectively, Melero reported.
Melero I, Sangro B, Yau T, et al. Nivolumab dose escalation and expansion in patients with advanced hepatocellular carcinoma: the CheckMate 040 study. Abstract presented at: 2017 Gastrointestinal Cancers Symposium; January 19-21, 2017; San Francisco, CA.

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