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Pegylated Doxorubicin/Carboplatin Plus Bevacizumab Improves PFS in Recurrent Ovarian Cancer

Wayne Kuznar
Published: Wednesday, Nov 14, 2018

Jacobus Pfisterer, MD, PhD

Jacobus Pfisterer, MD, PhD

The combination regimen of pegylated liposomal doxorubicin (CD-BEV) with bevacizumab (Avastin) was found to significantly improve progression-free survival (PFS) versus carboplatin/gemcitabine (CG-BEV) in patients with recurrent disease whose first recurrence was longer than 6 months following frontline platinum-based chemotherapy, according to phase III findings presented at the 2018 ESMO Congress.

 
There was also a trend toward an improvement in median overall survival (OS) with CD-BEV compared with CG-BEV that did not achieve significance (33.5 vs 28.2 months; HR, 0.833; 95% CI, 0.680-1.022; stratified log-rank P = .0787).

A total of 682 patients with recurrent ovarian cancer suitable for platinum-based retreatment were randomized 1:1 to standard treatment (CG-BEV) or the experimental treatment (CD-BEV). In the standard arm, bevacizumab was given as 15 mg/kg on day 1, followed by gemcitabine (1,000mg/m² on days 1 and 8) and carboplatin (AUC4 on day 1) every 3 weeks for up to 6 cycles in the absence of progression disease or unacceptable toxicities.

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