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Pembrolizumab/Axitinib Favored as Frontline Standard in mRCC

Caroline Seymour
Published: Wednesday, Mar 20, 2019

Thomas Powles, MBBS, MRCP, MD

Thomas Powles, MBBS, MRCP, MD
The combination of pembrolizumab (Keytruda) and axitinib (Inlyta) is favored as the frontline standard of care for patients with metastatic clear cell renal cell carcinoma (RCC) following data from the pivotal phase III KEYNOTE-426 trial, said Thomas Powles, MBBS, MRCP, MD.

In the long-anticipated trial, investigators randomized patients to receive either the combination of pembrolizumab and axitinib or sunitinib (Sutent) monotherapy. Results indicated a 47% reduction in the risk of death and a 31% reduction in the risk of disease progression or death. The median progression-free survival (PFS) was 15.1 versus 11.1 months with the combination versus single-agent sunitinib, respectively,1 and the median overall survival (OS) was not yet reached in either arm.

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