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PFS Benefit Confirmed With Daratumumab Plus VMP in Newly Diagnosed Myeloma

Shannon Connelly
Published: Monday, Jan 21, 2019

Maria-Victoria Mateos, MD, PhD

Maria-Victoria Mateos, MD, PhD
Daratumumab (Darzalex) in combination with bortezomib (Velcade), melphalan, and prednisone (VMP) continued to significantly improve progression-free survival (PFS) in patients with newly diagnosed multiple myeloma, according to updated findings of the phase III ALCYONE study.

during the 2018 ASH Annual Meeting, Mateos discussed the updated findings from the ALCYONE trial in patients with newly diagnosed multiple myeloma.

OncLive: Can you give some background on this study?

Mateos: Multiple myeloma usually affects the elderly population. In fact, it's the second most frequent hematologic malignancy. Most patients with multiple myeloma are not eligible for autologous stem cell transplantation. Bortezomib plus melphalan and prednisone has been a standard of care that we have used for this population for many years. Daratumumab is an anti-CD38 monoclonal antibody that has shown to be very effective as a single agent and in combination with either bortezomib or lenalidomide in relapsed and refractory myeloma patients.
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