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Powles Navigates Rapidly Evolving Frontline Paradigm in Urothelial Carcinoma

Angelica Welch
Published: Wednesday, Dec 12, 2018


Thomas Powles, MBBS
After a wave of success with checkpoint inhibitors, the frontline setting of bladder cancer has been a space of uncertainty, according to Thomas Powles MBBS, MRCP, MD.

, Powles, professor of genitourinary oncology, lead, Solid Tumour Research, Barts Cancer Institute, director, Barts Cancer Centre, discussed the changes to the frontline landscape of bladder cancer and where research should focus moving forward.

OncLive: How is the frontline treatment of bladder cancer changing?

Powles: The frontline treatment of bladder cancer is evolving very quickly. It is actually evolving quicker than it ever has before. The immune checkpoint inhibitors were approved in the frontline setting in patients who are ineligible for cisplatin-based therapy, which was cool. It is a big step in the right direction, because chemotherapy is not associated with long-term durable remissions. But, the immune checkpoint inhibitors seem to lose control in large groups of patients, and only seem active in maybe 1 in 8 or 1 in 5 patients. It looks as if half of the patients may be getting no benefit at all. Chemotherapy helps most patients a bit.
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