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Progress Continues in EGFR+ NSCLC Paradigm

Caroline Seymour
Published: Monday, Jul 16, 2018

Charu Aggarwal, MD, MPH

Charu Aggarwal, MD, MPH
Recent progress in the treatment paradigm for EGFR-mutant non–small cell lung cancer (NSCLC) includes the FDA’s frontline approval of osimertinib (Tagrisso) and priority review designation for dacomitinib, both of which have demonstrated longer progression-free survival (PFS) and overall survival (OS) outcomes versus standard therapy, said Charu Aggarwal, MD.

-mutant lung cancer.

OncLive: Can you discuss recent advances in EGFR-mutant NSCLC?

Aggarwal: I spoke about the preferential use of osimertinib (Tagrisso), which is our third-generation tyrosine kinase inhibitor (TKI) in the first-line setting. That offers patients a tremendous opportunity to live longer, as well as avoid some of the other side effects with first- or second-generation TKIs.
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