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Published Data Back Regorafenib Dose Escalation in Colorectal Cancer

OncLive Staff
Published: Wednesday, Jul 03, 2019

Tanios Bekaii-Saab, MD

Tanios Bekaii-Saab, MD
A weekly regorafenib (Stivarga) dose-escalation strategy beginning at 80 mg and ending at 160 mg is an appropriate and potentially optimal approach for previously treated patients with metastatic colorectal cancer (mCRC), according to data from the phase II ReDOS trial now published in the Lancet Oncology.

Bekaii-Saab TS, Ou F-S, Ahn DH, et al. Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study [published online June 28, 2019]. Lancet Oncol. doi:

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