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Radiation Role Remains Uncertain in High-Risk Endometrial Cancer

Danielle Bucco
Published: Tuesday, Feb 20, 2018

David G. Mutch, MD

David G. Mutch, MD
Following the results of a number of clinical studies, researchers are still debating the role of radiation therapy for patients with high-risk endometrial cancer.

during the 2018 Society of Gynecologic Oncology Annual Winter Meeting, Mutch, the Ira C. and Judith Gall Professor, vice chair of obstetrics and gynecology, chief of the Division of Gynecologic Oncology, Washington University School of Medicine in St. Louis, Siteman Cancer Center, discussed ongoing questions surrounding the role of radiation therapy for patients with high-risk endometrial cancer.

OncLive: Please discuss the use of external beam radiation therapy in high-risk patients with endometrial cancer.

Mutch: I am in a debate [at this meeting] on whether there is utility in giving patients with high-risk endometrial cancer radiation therapy. My argument against this is supported by several trials beginning with GOG-99, which identified a high- and intermediate-risk group of patients with endometrial cancer. There was a decreased risk of central disease but not an OS benefit to postoperative external beam radiation therapy. 
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