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Ramucirumab/Erlotinib Combo Improves PFS in Frontline EGFR+ NSCLC

Gina Columbus @ginacolumbusonc
Published: Tuesday, Mar 12, 2019

Dr Maura N. Dickler

Maura N. Dickler, MD

The combination of ramucirumab (Cyramza) and erlotinib (Tarceva) significantly improved progression-free survival (PFS) compared with placebo and erlotinib as a frontline treatment for patients with metastatic EGFR-mutant non–small cell lung cancer (NSCLC), meeting the primary endpoint of the RELAY trial (NCT02411448).1



  1. Lilly's Cyramza® (Ramucirumab) Phase 3 RELAY Trial Met Primary Endpoint, Significantly Improving Progression-Free Survival in First-Line Treatment of Patients With Metastatic EGFR-Mutated Non-Small Cell Lung Cancer. Eli Lilly and Company. Published March 12, 2019. Accessed March 12, 2019.
  2. Garon EB, Ciuleanu T-E, Arrieta O, et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet Oncol. 2014;384(9944):665-673. doi: 10.1016/S0140-6736(14)60845-X.

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