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Real-World Findings Support Nivolumab Use in HNSCC

Angelica Welch
Published: Wednesday, Dec 12, 2018

Nivolumab (Opdivo) demonstrated durable response and overall survival (OS) rates in a real-world analysis of patients with platinum-refractory, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).1 These findings support the CheckMate-141 safety and activity data in this population, which historically has had a poor prognosis.

“These promising results encourage the use of nivolumab in this population, but further follow-up and more mature data are still needed,” concluded Bruixola and colleagues.


  1. Bruixola G, Caballero Daroqui J, Cunquero Tomas AJ, et al. Safety and efficacy of nivolumab (nivo) in platinum-refractory recurrent/metastatic head and neck squamous cell (PR R/M HNSCC) patients (pts): real-life experience. Ann Oncol. 2018;29(Suppl 8):viii372-viii399. doi: 10.1158/1538-7445.AM2018-CT116.
  2. Ferris RL, Blumenschein GR, Fayette J, et al. Nivolumab (Nivo) vs investigator’s choice (IC) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): 2-yr outcomes in the overall population and PD-L1 subgroups of CheckMate 141. In: Proceedings from the American Association for Cancer Research Annual Meeting 2018; April 14-18, 2018; Chicago, Illinois. Abstract CT116. doi: 10.1158/1538-7445.AM2018-CT116.

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TitleExpiration DateCME Credits
Medical Crossfire®: How Can We Optimize Outcomes in Head and Neck Cancers with Immunotherapeutic Strategies?Oct 31, 20191.5
Community Practice Connections™: ASCO Direct™ Highlights – 2019 Official Annual Meeting ReviewAug 30, 20201.5
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