The incorporation of real-world data is becoming increasingly important in the daily use of anticancer agents, according to Juan Manuel O’Connor, MD. In a presentation of the final results from the prospective, observational CORRELATE study at the 2018 ESMO Congress, real-world dosing data were released for regorafenib (Stivarga) in patients with metastatic colorectal cancer (mCRC).1
during the 2018 ESMO Congress, O'Connor, head, Department Gastrointestinal Oncology, Department of Clinical Oncology, Institute Alexander Fleming, Buenos Aires, discussed the final results of the CORRELATE regorafenib study in patients with mCRC, emphasizing the importance of real-world data.
OncLive: Could you please share the final results from CORRELATE?
The approval dose of regorafenib for the treatment of patients with mCRC is 160 mg. There are some differences between the real-world setting and the patients included in the randomized clinical trial. The aim of our study was to look at the data from the real-world setting of refractory mCRC in more detail.
The final results of our study described a starting dose in patients based on the decisions of the treating physicians. Of the patients enrolled on the study, 57% of those who started at the recommended dose of 160 mg, 30% at 120 mg, and 13% at 80 mg. That is very important information.
What are your thoughts on regorafenib in a dose-escalation regimen?
There were very important data from the ReDOS trial based on the escalation and re-escalation. In our study, around 20% of our patients required an escalated dose. We plan to analyze this subgroup based on the new data coming from the ReDOS trial.
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