Responses to ruxolitinib (Jakafi) in patients with polycythemia vera (PV) were maintained by a majority of primary responders at 4 years’ follow-up, according to an updated analysis of the RESPONSE trial presented at the 2017 ASH Annual meeting.1
Two on-treatment deaths occurred in the ruxolitinib arm since the week-80 analysis (gastric cancer and unspecified malignant neoplasm, neither considered related to treatment). Additionally, 4 on-treatment fatal AEs occurred among patients who crossed over to ruxolitinib, but none were considered related to treatment with ruxolitinib.
- Kiladjian JJ, Verstovsek S, Griesshammer M, et al. Results from the 208-week (4-Year) follow-up of RESPONSE trial, a phase 3 study comparing ruxolitinib (Rux) with best available therapy (BAT) for the treatment of polycythemia vera (PV). Presented at: 2017 ASH Annual Meeting; December 9-12, 2017; Atlanta, GA. Abstract 322.
- Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372(5):426-435. doi: 10.1056/NEJMoa1409002.
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