Jan van de Winkel, PhD
A subcutaneous (SC) formulation of daratumumab is noninferior in inefficacy and pharmacokinetics compared with standard intravenous (IV) daratumumab (Darzalex) in patients with relapsed/refractory multiple myeloma, according to data from the phase III COLUMBA study.1
Additionally, the safety profiles were similar across both dosing regimens.
- Genmab Announces Positive Topline Results in Phase III COLUMBA Study of Subcutaneous Daratumumab. Published February 25, 2019. Accessed February 25, 2019. https://bit.ly/2tCig7V.
- Chari AJ, Martinez-Lopez J, Mateos MV, et al. Daratumumab (DARA) in combination with carfilzomib and dexamethasone (D-Kd) in lenalidomide (Len)-refractory patients (Pts) with relapsed multiple myeloma (MM): Subgroup analysis of MMY1001. J Clin Oncol. 2018;36 (suppl; abstr 8002).
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