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Surgery and Adjuvant RT Show Superiority in Locally Advanced Prostate Cancer

Caroline Seymour
Published: Tuesday, Nov 20, 2018

Grace Lu-Yao, PhD

Grace Lu-Yao, PhD

Higher survival rates were observed with radical prostatectomy (RP) and adjuvant radiotherapy (RT) compared with radiotherapy and androgen deprivation therapy (ADT) in men with locally advanced prostate cancer, according to a comparative analysis published in Cancer.1,2

Moving forward, the authors noted there should be a surgical arm in future clinical trials for men with high-risk prostate cancer in addition to prospective trial data to confirm these findings.


  1. Jefferson University Hospitals (2018). Combination therapy of prostatectomy plus radiotherapy may improve survival in patients with locally advanced prostate cancer. Published September 25, 2018. Accessed 4 Oct. 2018.
  2. Jang TL, Patel N, Faiena I, et al. Comparative effectiveness of radical prostatectomy with adjuvant radiotherapy versus radiotherapy plus androgen deprivation therapy for men with advanced prostate cancer [published online September 25, 2018]. Cancer. doi: 10.1002/cncr.31726.

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