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The Rapidly Changing Landscape in RCC Therapy: What Future Research May Hold

Bradley Carthon, MD, PhD
Published: Wednesday, Oct 24, 2018

Bradley Carthon, MD, PhD

Bradley Carthon, MD, PhD

Assistant Professor
Department of Hematology and Medical Oncology
Emory University School of Medicine
Approximately 43,000 cases of kidney cancer in men and 23,000 cases in women will occur in the United States in 2018.1 Almost 90% of those cases will be renal cell carcinoma (RCC), generally affecting individuals between the ages of 50 and 70.1,2 There are varying histologies that make up RCC, with clear cell histology being the most common, accounting for 70% of all cases.2 No singular cause of kidney cancer, including RCC, is known.2 However, certain risk factors have been identified, including obesity, smoking, environmental exposures and family history or genetics.2

Current Research Focused on Advanced Disease

Given the unmet needs for patients with metastatic RCC, much of the research on treatment has been for this specific population. As such, molecularly targeted systemic therapies for advanced RCC have today often supplanted previously used therapies that are no longer supported by guidelines.9,10 The current research landscape may be roughly divided into 3 broad categories based on therapeutic targets: antiangiogenic agents, related molecular pathways such as the mTOR pathway, and immunotherapies—including cytokine therapy.9
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Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of ImmunotherapyAug 13, 20191.5
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