The UK’s National Institute for Health and Care Excellence has approved olaparib (Lynparza) for the maintenance treatment of adult patients with relapsed, platinum-sensitive, high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer whose disease responded to platinum-based chemotherapy and harbor BRCA1/2
Before this expanded indication, olaparib was available as a capsule formulation within NHS England and Wales via routine commissioning for patients with relapsed BRCA-
mutant ovarian cancer who had received ≥3 lines of chemotherapy. With the updated indication, olaparib is now available as a tablet formulation for these patients, as well as for patients within NHS England via the Cancer Drugs Fund (CDF) if they have had 2 courses of platinum-based chemotherapy.
The new indication is based on findings from the phase III SOLO2 and the phase II Study 19 trials. SOLO2 showed a clinically meaningful and statistically significant improvement in progression-free survival (PFS) at 19.1 months with olaparib compared with 5.5 months with placebo (HR, 0.30; 95% CI, 0.22-0.41; P
<.0001) via investigator assessment. The estimated 2-year PFS rates were 43% and 15%, respectively.2
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