Joyce F. Liu, MD, MPH
In follow-up results to data first presented in December 2016, investigators found that the combination of olaparib (Lynparza) and cediranib maleate continued to show superior progression-free survival (PFS) compared with olaparib alone for women with BRCA-negative recurrent platinum-sensitive ovarian cancer.1
Liu said that investigators are recruiting patients for phase III trials of the combination in both the platinum-sensitive and platinum-resistant settings. “It is important that we are going to be looking at the biomarkers to help distinguish whether it is the non-carriers of germline BRCA mutations who are going to benefit the most from an antiangiogenic and a PARP inhibitor.”
- Liu J, Barry WT, Birrer M, et al. Overall survival and updated progression-free survival results from a randomized phase 2 trial comparing the combination of olaparib and cediranib against olaparib alone in recurrent platinum-sensitive ovarian cancer. J Clin Oncol. 2017;35 (suppl; abstr 5535).
- Liu JF, Barry WT, Birrer M, et al. Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study. Lancet Oncol. 2014;15:1207-1214.
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