Trung Nguyen, DO, MBA
Several trials have compared the use of neoadjuvant chemotherapy with primary debulking surgery in patients with newly diagnosed advanced ovarian cancer, and though the jury is still out, Trung Nguyen, DO, MBA, explained that the field continues to evolve as novel therapies such as angiogenesis inhibitors, PARP inhibitors, and immunotherapy enter the landscape.
“We are in an era of having different available options in terms of treatment. We're starting to realize that the genetic heterogeneity of ovarian cancer plays a big role in how we treat the patient and how the patient responds,” said Nguyen. “There won't be a one-size-fits-all approach. All of our patients will have to be treated with an individualized approach, both from a survival perspective and the patient’s goals of care.”
For patients who harbor BRCA
mutations, olaparib (Lynparza) may become another option for physicians to choose from following the FDA’s decision to grant a priority review designation to a supplemental drug application (sNDA) for the PARP inhibitor as frontline maintenance treatment for patients with newly diagnosed, BRCA
-positive advanced ovarian cancer following a complete or partial response to standard frontline platinum-based chemotherapy.1
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