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Vorasidenib, Ivosidenib Show Encouraging Activity in IDH1-Mutant Low-Grade Glioma

Gina Columbus @ginacolumbusonc
Published: Monday, Nov 25, 2019

Ingo K. Mellinghoff, MD, acting co-chair and vice chair for Research in the Department of Neurology, chief of Brain Tumor Service, and Evnin Family Chair in Neuro-Oncology of Memorial Sloan Kettering Cancer Center

Ingo K. Mellinghoff, MD

Single-agent vorasidenib or ivosidenib (Tibsovo) led to brain penetrance and 2-hydroxyglutarate (2-HG) suppression in patients with low-grade glioma who harbor IDH1 mutations, according to updated data from an ongoing, 2-cohort, perioperative study (NCT03343197) that were presented at the 2019 Society for Neuro-Oncology Annual Meeting.
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