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Zoptarelin Doxorubicin Falls Short in Phase III Endometrial Cancer Trial

Jason Harris
Published: Friday, May 05, 2017

Emese Zsiros, MD, PhD

Emese Zsiros, MD, PhD

Zoptarelin doxorubicin (Zoptrex), a hybrid molecule combining an LHRH-agonist and doxorubicin, failed to improve median overall survival (OS) in a phase III advanced endometrial cancer trial, according to the manufacturer of the treatment, Aeterna Zentaris.

The FDA rejected macimorelin in 2014, saying that Aeterna Zentaris would have to conduct a new trial to demonstrate efficacy.
Emons G, Grigor G, Harter P, et al. Efficacy and safety of AEZS-108 (LHRH agonist linked to doxorubicin) in women with advanced or recurrent endometrial cancer expressing LHRH receptors: a multicenter phase 2 trial (AGO-GYN5). Int J Gynecol Cancer. 2014;24:260-265.

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