AR Emerges as a Potential Target in Triple-Negative Breast Cancer
Whereas the androgen receptor (AR) is a common target in prostate cancer, emerging findings are showing a potential role for targeting AR in breast cancer, as well.
HER2 Gene Testing Guidelines May Misclassify Patients
Michael F. Press, MD, PhD, discusses issues with the ASCO-CAP guidelines on assessment of HER2 amplification by fluorescence in situ hybridization testing.
Expert Discusses Biomarkers for PARP Inhibitors in Ovarian Cancer
Dr. Elizabeth Swisher discusses biomarkers for PARP inhibitors and the evolving role of these agents in ovarian cancer.
Mirvetuximab Soravtansine Active in Platinum-Resistant Ovarian Cancer
Results of a phase I expansion study demonstrated a manageable safety profile and clinical activity with mirvetuximab soravtansine in the treatment of patients with platinum-resistant ovarian cancer.
Rovalpituzumab Tesirine Active and Safe in Small Cell Lung Cancer
Rovalpituzumab tesirine demonstrated encouraging single-agent antitumor activity with a manageable safety profile in the treatment of patients with recurrent small cell lung cancer.
Intentional Weight Loss Linked to Reduction in Endometrial Cancer Risk
Intentional weight loss in postmenopausal women has been found to be associated with a lower endometrial cancer risk, particularly among those with obesity, according to the results of a recent study published in the Journal of Clinical Oncology.
Disparities in Cervical Cancer Mortality Rates Highlight Need for Specialized Treatment
Anne Rositch, PhD, discusses important takeaways from her study on hysterectomy-corrected mortality rates in cervical cancer and the significance of cervical cancer screening.
Adding Antiandrogen Therapy to Radiation Improves Survival in Recurrent Prostate Cancer
The addition of hormonal therapy to radiation treatment following surgery significantly improved survival in patients with recurrent prostate cancer, according to the results of a study published in The New England Journal of Medicine.
Laparoscopy Plays Predictive Role for Primary Surgery Outcomes in Ovarian Cancer
Diagnostic laparoscopy reduced the number of futile laparotomies in patients with suspected advanced-stage ovarian cancer, according to the results of a recent study.
New Marker May Identify Men Who Require More Aggressive Prostate Cancer Treatment
A prostate-specific antigen nadir greater than 0.5 ng/mL following radiation and androgen deprivation therapy seems to identify men prior to PSA failure who are at high-risk for death, and would thus require more aggressive treatment for their prostate cancer.
Expert Discusses Updated HPV Vaccine Recommendations
Lois Ramondetta, MD, discusses the updated recommendations and the importance of advocating for lesser-known HPV-associated cancers.
Researchers Reveal New Subtype of Cervical Cancer
Carolyn E. Banister, MD, discusses the results of a study that uncovered a new subtype of cervical cancer, as well as some of the remaining challenges in the overall treatment landscape.
Prostate Cancer Treatment Rates Drop Following Changes in Screening Recommendations
A sharp decline has been observed in the overall rate of men receiving treatment for prostate cancer.
Expert Discusses Role of Vaginal Microbes in Endometrial Cancer Detection
A direct assessment of the uterine microbiome in patients with endometrial cancer has revealed a potential predictive role for vaginal microbes.
Watch-and-Wait Approach a Potential Option for Patients With Rectal Cancer
A watch-and-wait approach is emerging as a potential treatment strategy for patients with rectal cancer.
Novel Biomarker May Predict Recurrence in HPV+ Oropharyngeal Cancer
In the current treatment landscape of HPV-positive oropharyngeal squamous cell carcinoma, there is a significant lack of biomarkers to predict recurrence.
Early Endometrial Cancer Mutations Detectable in Uterine Lavage Fluid
As mortality rates continue to climb in endometrial cancer, there remains a pressing need for effective screening and diagnostics.
HER2 Vaccine Shows Promise in Early-Stage Breast Cancer
Anti-HER2 DC1 vaccination was demonstrated to be a safe and immunogenic treatment to induce tumor-specific T-cell responses in patients with HER2-positive breast cancer.
Herbst Discusses Next Steps With Pembrolizumab in Lung Cancer
Roy Herbst, MD, PhD, discusses the next steps with pembrolizumab in NSCLC, PD-L1 testing, and managing increased toxicities with combination regimens.
Expert Discusses Factors Associated With Local Control in Ewing Sarcoma
According to Dimosthenis Andreou, MD, patients with pelvic Ewing sarcoma have poorer local control and poorer overall survival.
Expert Highlights Efficacy of KTE-C19 CAR T-Cell Therapy in Non-Hodgkin Lymphoma
KTE-C19, an investigational CAR T-cell therapy, recently demonstrated positive results for patients with chemorefractory aggressive non-Hodgkin lymphoma.
Reduced-Dose Radiation Effective in HPV-Associated Oropharynx Cancers
Induction chemotherapy followed by reduced-dose radiation and weekly cetuximab demonstrated improved swallowing and nutritional status as well as an excellent complete clinical response for patients with HPV-associated oropharyngeal squamous cell carcinoma.
R-CHOP Remains Frontline Standard in DLBCL, Says Expert
The regimen of rituximab plus CHOP chemotherapy has been the standard of care for patients with previously untreated diffuse large B-cell lymphoma for several years, and it appears it will remain that way for now, despite recent research to find novel alternatives.
Expert Discusses "Sequential Triple-T" Trials in CLL
In the treatment paradigm of chronic lymphocytic leukemia, anti-CD20 antibodies such as obinutuzumab, and other targeted agents like ibrutinib, have shown promising efficacy and tolerability when compared with standard chemoimmunotherapy.
CT-Planned, High-Dose-Rate Brachytherapy Effective in Cervical Cancer
The use of CT-planned high-dose-rate intracavitary brachytherapy demonstrated excellent local control and survival for patients with stage I/II cervical carcinoma, according to the results of a recent study published in Gynecologic Oncology.
Expedited Surgery Increases Mortality Risk in Endometrial Cancer
Patients with endometrial cancer who receive surgery in the first 2 weeks after diagnosis have worse survival outcomes, according to a study recently reported in the American Journal of Obstetrics and Gynecology.
Study Links NSAIDs to Increased Mortality in Endometrial Cancer
An association was found between the use of nonsteroidal anti-inflammatory drugs and endometrial cancer risk.
Distinct, Aggressive Subgroup of ACC Identified With Activating NOTCH1 Mutations
NOTCH1 mutations have been found to define an aggressive subgroup of patients with adenoid cystic carcinomas, with a corresponding pattern of metastatic spread.
Concomitant Chemo Regimens Most Effective for Locally Advanced Nasopharyngeal Carcinoma
The addition of chemotherapy, either adjuvant or induction, to concomitant chemoradiotherapy achieved a significantly high survival benefit for patients with locally advanced nasopharyngeal carcinoma.
Entospletinib Shows Modest Activity in Mantle Cell Lymphoma
Entospletinib was well tolerated and demonstrated modest activity in patients with relapsed or refractory mantle cell lymphoma.
Isa-KRd Elicits MRD-Negative Remissions in Newly Diagnosed, High-Risk Myeloma
KIT Inhibitors Lead to Shift in Treatment of Systemic Mastocytosis
Smoldering Multiple Myeloma Management Hinges on the Debate Between Treatment and Observation
Lung Responses to Atezolizumab/Bevacizumab Linked With OS in HCC and Pulmonary Metastasis
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