Articles by Aparna R. Parikh, MD

Curative Intent, Local Therapy, and ctDNA in MSI-H Metastatic Colorectal Cancer
ByAparna R. Parikh, MD,Nicholas James Hornstein, MD, PhD,Mike J. Pishvaian, MD, PhD,Katrina S. Pedersen, MD, MS Experts discuss the evolving role of ctDNA in managing MSI-high cancer patients, emphasizing non-operative approaches and improved treatment strategies.

Advancing Precision Care in Unresectable Metastatic Colorectal Cancer – Immunotherapy in the First-Line Setting
ByAparna R. Parikh, MD,Nicholas James Hornstein, MD, PhD,Mike J. Pishvaian, MD, PhD,Katrina S. Pedersen, MD, MS Experts discuss recent advancements in precision care for unresectable metastatic colorectal cancer, focusing on innovative treatment strategies and biomarker roles.

Aparna Parikh, MD, discusses the importance of upfront molecular testing in patients with metastatic colorectal cancer.

Aparna Parikh, MD, discusses currently available treatment options for patients with HER2-positive colorectal cancer.

Aparna Parikh, MD, discusses currently available targeted therapy options for patients with colorectal cancer.

Key Takeaways and Closing Thoughts on ADCs
ByVK Gadi, MD, PhD,Susana M. Campos, MD, MPH,Matthew Galsky, MD,Edward B. Garon, MD, MS,Aparna R. Parikh, MD Experts discuss key takeaways and closing thoughts on antibody-drug conjugates (ADCs) in cancer treatment.

Emerging ADCs in Development
ByVK Gadi, MD, PhD,Susana M. Campos, MD, MPH,Matthew Galsky, MD,Edward B. Garon, MD, MS,Aparna R. Parikh, MD Key opinion leaders examine promising antibody-drug conjugates (ADCs) in the pharmaceutical development pipeline.

ADC Sequencing
ByVK Gadi, MD, PhD,Susana M. Campos, MD, MPH,Matthew Galsky, MD,Edward B. Garon, MD, MS,Aparna R. Parikh, MD Expert clinicians offer strategic guidance on optimal sequencing of antibody-drug conjugates (ADCs) in treatment protocols.

Aparna Parikh, MD, discusses the rationale for adding ERAS-007 to the BEACON regimen in BRAF V600E–mutated metastatic colorectal cancer.

Management of Emetogenicity of Antibody-Drug Conjugates
ByVK Gadi, MD, PhD,Susana M. Campos, MD, MPH,Matthew Galsky, MD,Edward B. Garon, MD, MS,Aparna R. Parikh, MD Experts provide clinical insights on the management of emetogenicity in patients receiving antibody-drug conjugates.

Managing Hematologic AEs Associated with ADC Treatments
ByVK Gadi, MD, PhD,Susana M. Campos, MD, MPH,Matthew Galsky, MD,Edward B. Garon, MD, MS,Aparna R. Parikh, MD A panel of experts discuss hematologic adverse events associated with antibody-drug conjugate therapies.

Managing Toxicities in Short- and Long-Term Treatment with ADCs
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Vijayakrishna Gadi, MD, PhD, discusses short-term and long-term treatments with ADCs.

Managing ILD and Pneumonitis Risk From ADCs
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Vijayakrishna Gadi, MD, PhD, discusses the risk of ILD and pneumonitis from ADCs.

The Potential Role for HER2-Targeted ADCs in Earlier Treatment Lines
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Vijayakrishna Gadi, MD, PhD, discusses the role of antibody-drug conjugates in a curative setting.

Overcoming Challenges of Testing for HER2-low Across Solid Tumor Types
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD A panel of experts discuss the challenges of testing for HER2-low access solid tumor types.

ADCs Targeting HER2+ GU Cancers
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD A panel of experts discuss if there is a role for HER2-directed ADCs antibody-drug conjugates in GU genitourinary cancers

Impact of ADCs on Brain Metastases
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD A panel of experts discuss where HER2-directed ADCs antibody-drug conjugates fit into the overall treatment paradigm.

ADCs Targeting HER2+ Lung Cancer
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Dr Garon shares insights on the role of ADCs for the treatment of HER2+ lung cancer.

Emerging Data from ASCO 2024 in HER2-low: DESTINY-Breast06
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Dr Gadi leads a discussion on recent data on the treatment of HER2-low tumors, including ASCO updates on the DESTINY-Breast06 trial.

ADCs Targeting GI Cancers
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Dr Parikh discusses the history of ADCs for treating GI cancers with a focus on the data for T-DXd and its role in treating these cancers.

ADCs Targeting HER2+ Gynecologic Cancers
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Dr Campos discusses the potential for T-DXd in other gynecologic cancers and offers an overview of results from the DESTINY-PanTumor02 trial.

Aparna Parikh, MD, discusses outcomes from the HERKULES-3 trial in BRAF V600E–mutated metastatic colorectal cancer.

ADCs Targeting HER2+ Breast Cancer
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Dr Gadi introduces treatment and trial data targeting care for patients diagnosed with HER2+ breast cancer.

Assessing HER2 Status Across Tumor Types
ByVijayakrishna Gadi, MD, University of Illinois College of Medicine,Susana Campos, MD, MPH,Matthew D. Galsky, MD,Edward Garon, MD, Jonsson Comprehensive Cancer Center at UCLA,Aparna R. Parikh, MD Dr Gadi leads a discussion surrounding HER2 mutation and overexpression across various cancer types.

Anticipating Key Studies and Pipeline Treatments in mCRC Landscape
ByAparna R. Parikh, MD,Marwan G. Fakih, MD,Richard Kim, MD,Scott Paulson, MD,Mark A. Lewis, MD,Joleen M. Hubbard, MD The experts provide their final thoughts surrounding the impact of prospective trials and therapy regimens for treating patients with refractory mCRC.

Unmet Needs Surrounding mCRC Treatment
ByAparna R. Parikh, MD,Marwan G. Fakih, MD,Richard Kim, MD,Scott Paulson, MD,Mark A. Lewis, MD,Joleen M. Hubbard, MD Key opportunities to improve the mCRC treatment landscape are illustrated by the expert panelists.

Data Surrounding Treatment for MSI-high Patients from ASCO 2024
ByAparna R. Parikh, MD,Marwan G. Fakih, MD,Richard Kim, MD,Scott Paulson, MD,Mark A. Lewis, MD,Joleen M. Hubbard, MD Dr Kim offers key perspective for MSI-high patients based on data presented at ASCO 2024.

Real-World Data Surrounding Sequencing Strategies for Refractory mCRC
ByAparna R. Parikh, MD,Marwan G. Fakih, MD,Richard Kim, MD,Mark A. Lewis, MD,Joleen M. Hubbard, MD,Scott Paulson, MD Multiple abstracts from ESMO 2023, including a focus on tumor location, are highlighted.

Treatment Sequencing for Refractory mCRC and SUNLIGHT Study Analysis
ByAparna R. Parikh, MD,Marwan G. Fakih, MD,Richard Kim, MD,Scott Paulson, MD,Mark A. Lewis, MD,Joleen M. Hubbard, MD Data presented at ESMO 2023 and ASCO GI 2024 highlight the impact of prior therapy, including VEGF inhibitors or fluoropyrimidine, on mCRC treatment approach.

Considerations for Platinum-based Therapy
ByAparna R. Parikh, MD,Marwan G. Fakih, MD,Richard Kim, MD,Scott Paulson, MD,Mark A. Lewis, MD,Joleen M. Hubbard, MD Key factors, particularly neuropathy, drive the discussion for platinum-based therapy for patients with non-refractory mCRC.