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ESMO 2020 News

ESMO 2020 News

September 19th 2020


We are reporting from the 2020 ESMO Virtual Congress!

We are recapping some of the top news that are being presented during the conference—and in just a bit we’ll be speaking with Dr Robert Coleman to get his take on the biggest abstracts in gynecologic cancers, and also with Dr Shilpa Gupta on the latest in genitourinary cancers.

Welcome to OncLive News Network! I’m Gina Mauro.

In renal cell carcinoma, results of the phase 3 CheckMate-9ER trial showed that the combination of nivolumab and cabozantinib was found to double progression-free survival and objective response rates, and also significantly improve overall survival, compared with sunitinib, in patients with advanced disease who have not received prior treatment.

In basal cell carcinoma, the PD-1 antibody cemiplimab established encouraging clinical activity in patients with locally advanced disease who progress on or are intolerant to hedgehog inhibitors, regardless of PD-L1 expression, according to primary cohort results of a phase 2 trial presented during the meeting.

In an interim analysis of a subset of patients with intrahepatic cholangiocarcinoma harboring FGFR2 fusions/rearrangements, the oral small molecule inhibitor futibatinib was shown to be efficacious and tolerable. Investigators recorded a 37.3% objective response rate in the analysis of 67 patients with at least 6 months of follow-up. One patient had complete response and 24 patients had partial response.

Findings from the phase 3 IPATunity trial showed that the combination of ipatasertib plus paclitaxel did not improve efficacy in patients with PIK3CA/AKT1/PTEN-altered hormone receptor–positive advanced breast cancer. However, follow-up for overall survival is ongoing.

A subgroup analysis from the phase 3 JAVELIN Bladder 100 trial demonstrated that frontline maintenance therapy with avelumab plus best supportive care provided an overall survival benefit compared with best supportive care alone across prespecified subgroups of patients whose disease had not progressed with frontline induction chemotherapy. Avelumab was approved by the FDA earlier in 2020 for this indication.

Two phase 2 trials in cervical cancer showcased activity with the PD-1 inhibitor balstilimab in patients with recurrent/metastatic disease. As a single agent, he response rate was 14% of all patients with the disease 19% in PD-L1–positive patients. For patients who received balstilimab plus the CTLA-4 inhibitor zalifrelimab, the ORRs were 22% and 27% in PD-L1–positive patients with recurrent/metastatic cervical cancer, respectively.

A first-in-human trial showed that the novel FAP-targeted 4-1BB agonist RO7122290 demonstrated an acceptable safety profile as a single agent and in combination with atezolizumab. Moreover, there were favorable pharmacokinetic and pharmacodynamic effects, and the preliminary antitumor activity supports further investigation in clinical trials.

For more coverage of the 2020 ESMO Virtual Congress, please be sure to visit

That’s all for today. Tomorrow on OncLive News Network: On Location, we’ll speak with Dr Scott Tagawa to get perspectives on other studies being presentted in genitourinary cancers, and Dr Stephen Liu to get the latest ESMO abstracts in lung cancer.

Thank you for watching OncLive News Network! I’m Gina Mauro. 

Which of the following stories from the 2020 ESMO Virtual Congress did you find most exciting?

Lenvatinib/Pembrolizumab Combo Shows Antitumor Activity in Previously Treated Advanced Solid Tumors
Frontline Ipatasertib/Abiraterone Regimen Shows Superior Radiographic PFS in PTEN-Loss mCRPC
Nivolumab/Chemo Improves PFS, Elicits Durable Responses in Gastric/GEJ Cancers
Updates in Frontline Treatment of Metastatic Liver Cancer

Updates in Frontline Treatment of Metastatic Liver Cancer

July 24th 2020

A National Perspective on the Multidisciplinary Management of Breast Cancer Through the COVID-19 Pandemic

A National Perspective on the Multidisciplinary Management of Breast Cancer Through the COVID-19 Pandemic

May 17th 2020

This OncLive® webinar will focus on the impact of COVID-19 in patients with breast cancer and the innovative ways in which treatment has evolved during this time. We will feature a panel of experts from the nation’s leading cancer centers, led by Eric P. Winer, MD, to discuss important topics and key information for treating patients with breast cancer.


  • Regional differences in the management of patients with breast cancer during the COVID-19 pandemic
  • Institutional best practices for treating patients with breast cancer that have the novel coronavirus or who may be at risk for developing it
  • Guidelines on the prioritization and management of patients with breast cancer


Eric P. Winer, MD

Professor, Medicine, Harvard Medical School

Director, Breast Oncology Center, Dana-Farber Cancer Institute

Physician Active Staff, Medicine, Brigham And Women's Hospital

Thompson Chair, Breast Cancer Research, Dana-Farber Cancer Institute

Lisa A. Carey, MD , FASCO

Richardson and Marilyn Jacobs Preyer Distinguished Professor for Breast Cancer Research

Deputy Director of Clinical Sciences

Lineberger Comprehensive Cancer Center

George W. Sledge Jr, MD

Professor, Medicine and Oncology

Chief of the Division of Oncology, Stanford University Medical Center

Monica Morrow, MD, FACS

Chief, Breast Service, Department of Surgery

Anne Burnett Windfohr Chair of Clinical Oncology

Memorial Sloan Kettering Cancer Center

Professor of Surgery, Weill Cornell Medical College

Sponsored by : Novartis / In association with Dana Farber