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Dr. Charles Ryan Discusses IMAAGEN Trial Update for Prostate Cancer

Charles J. Ryan, MD
Published: Thursday, Jun 23, 2016


Charles J. Ryan, MD, professor of Clinical Medicine, Urology, Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, provides an update to the IMAAGEN trial, which explored the effects of abiraterone acetate (Zytiga) and low-dose prednisone on prostate-specific antigen (PSA) and radiographic disease progression in patients with nonmetastatic castration-resistant prostate cancer (CRPC).

The phase II study is examining an important patient population, as there is no standard of care for them, Ryan explains, and most patients progress to metastatic disease.

The findings show that the addition of 5 mg of prednisone was not associated with significant adverse events, he says. Additionally, there was a high PSA response proportion of 90%, the time to PSA progression was 28 months, and the time to metastatic progression has not been determined.

Charles J. Ryan, MD, professor of Clinical Medicine, Urology, Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, provides an update to the IMAAGEN trial, which explored the effects of abiraterone acetate (Zytiga) and low-dose prednisone on prostate-specific antigen (PSA) and radiographic disease progression in patients with nonmetastatic castration-resistant prostate cancer (CRPC).

The phase II study is examining an important patient population, as there is no standard of care for them, Ryan explains, and most patients progress to metastatic disease.

The findings show that the addition of 5 mg of prednisone was not associated with significant adverse events, he says. Additionally, there was a high PSA response proportion of 90%, the time to PSA progression was 28 months, and the time to metastatic progression has not been determined.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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