Dr. Pal on the CheckMate-214 and CABOSUN Studies in RCC

Sumanta Kumar Pal, MD
Published: Friday, Oct 13, 2017



Sumanta Kumar Pal, MD, co-director of the Kidney Cancer Program at the City of Hope in Duarte, California, discusses the CheckMate-214 and CABOSUN trials for patients with renal cell carcinoma (RCC).

The randomized CheckMate-214 study investigated the combination of nivolumab (Opdivo) plus ipilimumab (Yervoy) versus sunitinib (Sutent). This study appeared to have an overall survival benefit and a benefit in response rate. There was no significant difference in terms of progression-free survival (PFS).

In contrast, the CABOSUN study randomized patients to sunitinib or cabozantinib (Cabometyx) and showed a benefit in terms of PFS with cabozantinib. Both cabozantinib and nivolumab plus ipilimumab showed improvement versus sunitinib.
 


Sumanta Kumar Pal, MD, co-director of the Kidney Cancer Program at the City of Hope in Duarte, California, discusses the CheckMate-214 and CABOSUN trials for patients with renal cell carcinoma (RCC).

The randomized CheckMate-214 study investigated the combination of nivolumab (Opdivo) plus ipilimumab (Yervoy) versus sunitinib (Sutent). This study appeared to have an overall survival benefit and a benefit in response rate. There was no significant difference in terms of progression-free survival (PFS).

In contrast, the CABOSUN study randomized patients to sunitinib or cabozantinib (Cabometyx) and showed a benefit in terms of PFS with cabozantinib. Both cabozantinib and nivolumab plus ipilimumab showed improvement versus sunitinib.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
34th Annual Miami Breast Cancer Conference® Clinical Case Vignette Series™May 25, 20182.0
Community Practice Connections™: CDK4/6 Inhibitors With the Experts: The Role of Emerging Agents for the Management of Metastatic Breast CancerMay 30, 20182.0
Publication Bottom Border
Border Publication
x