Dr. Powles on the Results of the KEYNOTE-426 Trial in mRCC

Thomas Powles, MBBS, MRCP, MD
Published: Friday, Mar 15, 2019



Thomas Powles, MBBS, MRCP, MD, director, Barts Cancer Institute, discusses the results of the KEYNOTE-426 trial in metastatic renal cell carcinoma (mRCC).

KEYNOTE-426 showed that the combination of pembrolizumab (Keytruda) and axitinib (Inlyta) was superior to sunitinib (Sutent) monotherapy in patients with metastatic clear cell RCC, says Powles. The survival benefit translated to a risk reduction of 47% (HR, 0.53; 95% CI, 0.38-0.74; P <.0001). Though, the median overall survival was not reached in either arm. That's an unprecedented survival advantage in this setting, adds Powles.

This study speaks to the power of combining a VEGF inhibitor and a PD-1 inhibitor. Historically, the trials that were conducted with sunitinib only showed a benefit in progression-free survival. Although the VEGF-targeted therapies have moved the field forward steadily over the years, physicians have not seen such a dramatic improvement in survival in the frontline setting. These results will have an immediate impact on the way physicians think about kidney cancer, concludes Powles.
SELECTED
LANGUAGE


Thomas Powles, MBBS, MRCP, MD, director, Barts Cancer Institute, discusses the results of the KEYNOTE-426 trial in metastatic renal cell carcinoma (mRCC).

KEYNOTE-426 showed that the combination of pembrolizumab (Keytruda) and axitinib (Inlyta) was superior to sunitinib (Sutent) monotherapy in patients with metastatic clear cell RCC, says Powles. The survival benefit translated to a risk reduction of 47% (HR, 0.53; 95% CI, 0.38-0.74; P <.0001). Though, the median overall survival was not reached in either arm. That's an unprecedented survival advantage in this setting, adds Powles.

This study speaks to the power of combining a VEGF inhibitor and a PD-1 inhibitor. Historically, the trials that were conducted with sunitinib only showed a benefit in progression-free survival. Although the VEGF-targeted therapies have moved the field forward steadily over the years, physicians have not seen such a dramatic improvement in survival in the frontline setting. These results will have an immediate impact on the way physicians think about kidney cancer, concludes Powles.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Addressing Post-Transplant Obstacles: Current and Emerging Strategies to Evolve the Standard of Care for Patients With Graft-Versus-Host DiseaseMar 28, 20192.0
2017 Year in Review™: Clinical Impact of Immunotherapies in the Treatment of CancerMar 30, 20191.75
Publication Bottom Border
Border Publication
x