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EGFR-Mutant Advanced NSCLC: Frontline Choices, Sequencing, and Emerging Strategies

EP. 1: Introduction and Frontline Treatment Options for EGFR-Mutated NSCLC

ByBenjamin P. Levy, MD,D. Ross Camidge, MD, PhD, University of Colorado,Siddhartha Devarakonda, MD,Gilberto Lopes, MD,Julia K. Rotow, MD

Dr. Benjamin Levy introduces an expert panel to discuss the increasingly complex landscape of EGFR-mutant advanced non-small cell lung cancer (NSCLC) treatment. The frontline setting now includes three viable options representing a significant shift from the previously straightforward osimertinib monotherapy approach.

EP. 2: Shared Decision-Making and Risk Stratification in EGFR-Mutant NSCLC

ByBenjamin P. Levy, MD,D. Ross Camidge, MD, PhD, University of Colorado,Siddhartha Devarakonda, MD,Gilberto Lopes, MD,Julia K. Rotow, MD

Dr. Julia Rotow emphasizes shared decision-making as essential for frontline treatment selection, noting the dramatic shift from osimertinib monotherapy as standard to combination therapy as default over the past 2 to 3 years. Treatment decisions require balancing disease-associated risk factors with patient-specific considerations.